Natural Product Selection

Copious natural products are available to consumers via a wide variety of retail channels making a formidable task of natural product precipitant selection. A systematic method was developed to select and prioritize natural products to be studies as potential precipitants of natural product-drug interactions. Using this systematic method, an initial list of 46 commonly used natural products was focused to four high-priority products to be used as exemplars for the NaPDI recommended approaches.

Further details of the NaPDI recommended approach for selection of natural products for evaluation as potential precipitants of natural product-drug interactions can be found in the following NaPDI publication (click on the title to see the abstract in PubMed):

Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: A NaPDI Center Recommended Approach. Johnson EJ, González-Peréz V, Tian DD, Lin YS, Unadkat JD, Rettie AE, Shen DD, McCune JS, Paine MF. Drug Metab Dispos. 2018 Jul;46(7):1046-1052. doi: 10.1124/dmd.118.081273. Epub 2018 May 7. PMID: 29735752