Dissemination

Publications

2020

Paine MF. Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions. Drug Metab Dispos, 48(10):956-962, 2020. https://doi.org/10.1124/dmd.120.000182
PMID: 32816868 PMCID: In Progress

Birer-Williams C, Gufford BT, Chou E, Alilio M, VanAlstine S, Morley RE, McCune JS, Paine MF, Boyce RD. A New Data Repository for Pharmacokinetic Natural Product-Drug Interactions: From Chemical Characterization to Clinical Studies. Drug Metab Dispos, 48(10):1104-1112, 2020. https://doi.org/10.1124/dmd.120.000054
PMID: 32601103 PMCID: PMC7543481

Bansal S, Maharao N, Paine MF, Unadkat JD. Predicting the Potential for Cannabinoids to Precipitate Pharmacokinetic Drug Interactions via Reversible Inhibition or Inactivation of Major Cytochromes P450. Drug Metab Disp, 48(10):1008-1017, 2020. https://doi.org/10.1124/dmd.120.000073
PMID: 32587099 PMCID: In Progress

Flores-Bocanegra L, Raja HA, Graf TN, Augustinović M, Wallace ED, Hematian S, Kellogg JJ, Todd DA, Cech NB, Oberlies NH. The Chemistry of Kratom [Mitragyna speciosa]: Updated Characterization Data and Methods to Elucidate Indole and Oxindole Alkaloids. J Nat Prod, 83(7):2165-2177, 2020. https://doi.org/10.1021/acs.jnatprod.0c00257
PMID: 32597657

McDonald MG, Tian DD, Thummel KE, Paine MF, Rettie AE. Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects. Drug Metab Dispos, 48(10):1018-1027, 2020. https://doi.org/10.1124/dmd.120.091041
PMID: 32591416 PMCID: In Progress

Wallace ED, Todd DA, Harnly JM, Cech NB, Kellogg JJ. Identification of adulteration in botanical samples with untargeted metabolomics. Anal Bioanal Chem, 412(18):4273-4286, 2020. https://doi.org/10.1007/s00216-020-02678-6
PMID: 32347364 PMCID: In Progress

Gaston TE, Mendrick DL, Paine MF, Roe AL, Yeung CK. “Natural” is not synonymous with “Safe”: Toxicity of natural products alone and in combination with pharmaceutical agents. Regul Toxicol Pharmacol, 113:104642, 2020. https://doi.org/10.1016/j.yrtph.2020.104642
PMID: 32197968 PMCID: In Progress

Kellogg JJ, Kvalheim OM, Cech NB. Composite score analysis for unsupervised comparison and network visualization of metabolomics data. Anal Chim Acta, 1095:38-47, 2020. https://doi.org/10.1016/j.aca.2019.10.029
PMID: 31864629 PMCID: In Progress

2019

Tian DD, Natesan S, White JR J, Paine MF. Effects of common CYP1A2 genotypes and other key factors on intraindividual variation in the caffeine metabolic ratio: an exploratory analysis. Clin Translational Sci 12:39-46, 2019. https://dx.doi.org/10.1111%2Fcts.12598.
PMID: 30387917 PMCID: PMC63422440

Montonye ML, Tian DD, Arman T, Lynch KD, Hagenbuch B, Paine MF, Clarke JD. A pharmacokinetic natural product-disease-drug interaction: a double hit of silymarin and nonalcoholic steatohepatitis on hepatic transporters in a rat model. J Pharmacol Exper Ther, 371(2):385-393, 2019. https://doi.org/10.1124/jpet.119.260489.

Cox EJ, Maharao N, Patilea-Vrana G, Unadkat JD, Rettie AE, McCune JS, Paine MF. A marijuana-drug interaction primer: precipitants, pharmacology, and pharmacokinetics. Pharmacol Ther 201:25-38, 2019. https://doi.org/10.1016/j.pharmthera.2019.05.001
PMID: 31071346 PMCID: PMC6708768

Patilea-Vrana GI, Unadkat JD. Quantifying hepatic enzyme kinetics of tetrahydrocannabinol (THC) and its psychoactive metabolite, 11-OH THC, through in vitro modeling. Drug Metab Dispos 47:743-752, 2019. https://doi.org/10.1124/dmd.119.086470.

Birer C, Wright ES. Capturing the Complex Interplay Between Drugs and the Intestinal Microbiome. Clin Pharmacol Ther, 106(3):501-504, 2019. https://doi.org/10.1002/cpt.1505
PMID:31102465

Tian DD, Leonowens C, Cox EJ, González-Pérez V, Frederick KS, Scarlett YV, Fisher MB, Paine MF. Indinavir increases midazolam glucuronidation in humans: identification of an alternate CYP3A inhibitor using an in vitro to in vivo approach. Drug Metab Dispos 47:724-731, 2019. https://doi.org/10.1124/dmd.119.087007.
PMID: 31028057 PMCID: PMC6556520
[Figure selected for cover] 

Kellogg JJ, Paine MF, McCune JS, Oberlies NH, Cech NB. Selection and characterization of botanical natural products for research studies: a NaPDI center recommended approach. Nat Prod Rep 36:1196-1221, 2019. https://doi.org/10.1039/c8np00065d.

2018

Boyce RD, Ragueneau-Majlessi I, Yu J, Tay-Sontheimer J, Kinsella C, Chou E, Brochhausen M,  Judkins J, Gufford BT, Pinkleton BE, Cooney R,  Paine MF, McCune JS: “Developing User Personas to Aid in the Design of a User-Centered Natural Product-Drug Interaction Information Resource for Researchers” Proceedings of the 2018 Conference of the American Medical Informatics Association, Washington DC,  2018. 279-287.
PMID: 30815066 PMCID: PMC6371317.

Wallace ED, Oberlies NH, Cech NB, Kellogg JJ. Detection of Adulteration in Hydrastis canadensis (Goldenseal) Dietary Supplements via Untargeted Mass Spectrometry-based Metabolomics, Food Chem Toxicol 120:439-447, 2018. https://doi.org/10.1016/j.fct.2018.07.033.

Caesar LK, Kvalheim OM, Cech NB. Hierarchical Cluster Analysis of Technical Replicates to Identify Interferents in Untargeted Mass Spectrometry Metabolomics. Anal Chim Acta 1021: 69–77, 2018. https://doi.org/10.1016/j.aca.2018.03.013.
PMID: 29681286 PMCID: PMC5917943

Paine MF, Roe AL. “Green Medicine”: The Past, Present, and Future of Botanicals. Clin Pharmacol Ther 104:410-415, 2018. https://doi.org/10.1002/cpt.1168.
PMID: 30151884

Johnson EJ, González-Peréz V, Lin YS, Unadkat JD, Rettie AE, Shen DD, McCune JS, Paine MF. Selection of Priority Natural Products for Evaluation as Potential Precipitants of Natural Product-Drug Interactions: a NaPDI Center Recommended Approach. Drug Metab Dispos 46:1046-52, 2018. https://doi.org/10.1124/dmd.118.081273.
PMID: 29735752 PMCID: PMC6003438

Paine MF, Shen DD, McCune JS. Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary. Drug Metab Dispos 46:1041-5, 2018. https://doi.org/10.1124/dmd.117.079962.
PMID: 29735755 PMCID: PMC6003437

Judkins J, Tay-Sontheimer J, Boyce RD, and Brochhausen M. Extending the DIDEO Ontology to Include Entities from the Natural Product Drug Interaction Domain of Discourse. J Biomed Semantics 9:15, 2018. https://doi.org/10.1186/s13326-018-0183-z.
PMID: 29743102 PMCID: PMC5944177

Tian DD, Kellogg JJ, Okut N, Oberlies NH, Cech NB, McCune JS, Shen DD, Paine MF. Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea (Camellia sinensis) Using a Biochemometric Approach: Application to Raloxifene as a Test Drug via In Vitro to In Vivo Extrapolation. Drug Metab Dispos 46:552-60, 2018. https://doi.org/10.1124/dmd.117.079491

2017

Kellogg JJ, Wallace ED, Oberlies NH, Cech NB. Conventional and Accelerated-solvent Extractions of Green Tea (Camellia sinensis) for Metabolomics-Based Chemometrics. J Pharm Biomed Anal 145:604-610, 2017. https://doi.org/10.1016/j.jpba.2017.07.027.
PMID: 28787673 PMCID: PMC5804813

Kellogg JJ, Graf TN, Paine MF, McCune JS, Kvalheim OM, Oberlies NH, Cech NB. Comparison of Metabolomics Approaches for Evaluating the Variability of Complex Botanical Preparations: Green Tea (Camellia sinensis) as a Case Study. J Natr Prod 80:1457-66, 2017. https://doi.org/10.1021/acs.jnatprod.6b01156.
PMCID: PMC5469520

Poster Presentations

2019

Nguyen JT: Assessing the predictive performance of in silico generated binding parameters for various natural product constituents.” 12th international ISSX meeting, Portland, OR, July 28-31, 2019.

Tanna, RS: “The natural product kratom is a potential precipitant of pharmacokinetic interactions with common drugs of abuse.” 12th International ISSX meeting, Portland, OR, July 28-31, 2019.

Bansal S: “The potential of cannabinoids to precipitate drug interactions.” Gordon Picture2Research Conference on Drug Metabolism, Holderness, NH, July 8-12, 2019. Selected for 10-minute talk

Tanna RS: Assessing transporter-mediated goldenseal-drug interactions in healthy volunteers using a transporter cocktail.” Gordon Research Conference on Drug Metabolism, Holderness, NH, July 8-12, 2019. Selected for 10-minute talk

Bocanegra LF: “Chemical characterization of alkaloids from kratom (Mitragyna speciosa).” American Society of Pharmacognosy Conference, Madison, WI, July 13-17, 2019.

Tanna RS:  “Determining mechanisms underlying the goldenseal-midazolam interaction in humans using an in vitro to in vivo extrapolation approach.” EB/ASPET Annual Meeting, Orlando, FL, April 6-9, 2019. Selected for 3-minute talk

Tian DD:  Differential effects of silymarin on pitavastatin disposition in rodent models of simple fatty liver versus nonalcoholic steatohepatitis: a natural product-disease-drug interaction.” EB/ASPET Annual Meeting, Orlando, FL, April 6-9, 2019. Selected for 10-minute talk

2018

Wallace ED, Oberlies NH, Cech NB, Kellogg JJ: “Detection of Adulteration in Goldenseal Dietary Supplements via Mass Spectrometry-Based Metabolomics” International Conference on the Science of Botanicals, Oxford, MS, April 9-12, 2018. [1st Place Poster Award]

McCune JS, Tian DD, Hardy PA, Cech NB, Shen DD, Layton ME, White JR, Paine MF. Green tea decreases raloxifene systemic exposure to below the pre-defined no effect range in healthy volunteers. ASCPT Annual Meeting, Orlando, FL, March 22, 2018.

2017

Wallace ED, Oberlies NH, Cech NB, Kellogg JJ: “Detection of Adulteration in Goldenseal Dietary Supplements via Mass Spectrometry-Based Metabolomics” Southeast Regional Meeting of the American Chemical Society, Charlotte, NC, November 7-11, 2017.

Boyce RD, Ragueneau-Majlessi I, Yu J, Sontheimer J, Kinsella K, Brochhausen M, Judkins J, Pinkleton B, Cooney R, Paine MF, McCune JS: “Toward a Reliable and Interoperable Public Repository for Natural Product-Drug Interaction Study Data” 2017 Annual Symposium of the American Medical Informatics Association, Washington, DC, November 6, 2017. https://amia2017.zerista.com/poster/member/94177.

Wallace ED, Kellogg JJ, Graf TN, Oberlies NH: “Conventional and Accelerated-Solvent Extractions of Green Tea for Metabolomics-Based Chemometrics” American Society of Pharmacognosy Annual Meeting, Portland, OR, August 2, 2017.

Kellogg JJ, Graf TN, Kvalheim OM, Cech NB: “Comparison of MS and NMR Metabolomics for Evaluation of Herbal Supplements: a Case Study with Green Tea” 5th Annual Practical Applications of NMR in Industry Conference, Hilton Head Island, SC, February 22, 2017.

Kellogg JJ, Wallace ED, Graf TN, Oberlies NH, Cech NB: “Conventional and Accelerated-Solvent Extractions of Green Tea for Metabolomics-Based Chemometrics” 8th American Council for Medicinally Active Plants Conference, Clemson, SC, June 21, 2017.

Okut N, Kellogg JJ, Tian DD, Paine MF, Oberlies NH, Cech NB: “Biochemometrics to Identify Drug Metabolizing Enzyme Inhibitors from Green Tea (Camellia sinensis)” 8th American Council for Medicinally Active Plants Conference, Clemson, SC, June 21, 2017.

Tian DD, Kellogg JJ, Oberlies NH, Cech NB, McCune JS, Paine MF: “Identification of Intestinal UDP-Glucuronosyltransferase Inhibitors in Green Tea Using a Biochemometric Approach” Gordon Research Conference on Drug Metabolism, Holderness, NH, July 11, 2017.

Invited Oral Presentations

2019

Cech NB: “A plant by any other name: quality control of botanical natural products for research studies.” Linus Pauling Institute 10th International Conference, Corvallis, OR, August 14, 2019.

Paine MF: “Natural product-drug interaction research: cultivating best practices.” Linus Pauling Institute 10th International Conference, Corvallis, OR, August 14, 2019.

Paine MF: “Translational approaches to assess pharmacokinetic herb-drug Interactions.” 12th International ISSX Meeting, Portland, OR, July 29, 2019.

Unadkat JD: “Cannabinoid-drug interactions: getting into the weeds.” Gordon Research Conference on Drug Metabolism, Holderness, NH, July 9, 2019.

Paine MF: “Untangling mechanisms underlying natural product-drug interactions.” International Conference on Cytochrome P450, Brisbane, Australia, June 27, 2019.

Paine MF: “Clinical natural product-drug interactions: harvesting precipitants and mechanisms.” 22nd International Conference on Drug-Drug Interactions, Seattle, WA, June 20, 2019.

Thummel KE: Opening Remarks: “DDI hot topics.” 22nd International Conference on Drug-Drug Interactions, Seattle, WA, June 20, 2019.

Thummel KE: “Intestinal drug metabolizing enzymes and transporters: a review.” Symposium: Enteric Drug Metabolism and Drug-Drug Interactions. EB/ASPET Annual Meeting, Orlando, FL, April 9, 2019.

Paine MF: “Translational approaches to address potential clinically significant enteric xenobiotic-drug interactions: case study involving the herbal product green tea.” EB/ASPET Annual Meeting, Orlando, FL, April 9, 2019.

Kellogg JJ: “Techniques to identify bioactive constituents from complex mixtures: a biochemometrics approach.” Continuing Education Panel: Complex Mixtures and UVCBs: Analysis, Testing, and Risk Assessment. Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 10, 2019.

Paine MF: “Causative ingredients and mechanisms underlying interactions between prescription and non-prescription medications and natural products.” Society of Toxicology 58th Annual Meeting, Baltimore, MD, March 10, 2019.

2018

Paine MF: “Evaluating potential cannabis-drug interactions.” Cannabis Research Retreat, University of Washington, Seattle, WA, October 3, 2018.

Cech NB: “Untargeted metabolomics for assessing similarity, detecting adulteration, and identifying bioactive constituents in botanical dietary supplements.” Procter and Gamble, Cincinnati, OH, September 23, 2018.

Cech NB: “Untargeted metabolomics for assessing similarity, detecting adulteration, and identifying bioactive constituents in botanical dietary supplements.” National Institute of Environmental and Health Sciences, Durham, NC, September 12, 2018.

Clarke JC: “Overlapping Hits on Drug Disposition: Special Populations within Special Populations.” Gordon Research Conference on Drug Metabolism, Holderness, NH, July 12, 2018.

Paine MF: “Assessing Pharmacokinetic Natural Product-Drug Interactions: Challenges and Opportunities.” Delaware Valley Drug Metabolism Discussion Group – Rozman Memorial Symposium: Contributions of Women Scientists to Drug Metabolism, Drug Transporter, and Pharmacokinetics Research, Philadelphia, PA, June 14, 2018.

Paine MF: “Assessing a Pharmacokinetic Green Tea-drug Interaction from Bench to Bedsides” FDA, Center for Drug Evaluation and Research, Office of Clinical Pharmacology, Silver Spring, MD, June 5, 2018.

Paine MF: “Natural Product-drug Interactions: Progress Towards Recommend-ed Approaches” FDA, Center for Drug Evaluation and Research, Office of Clinical Pharmacology, Silver Spring, MD, May 25, 2018.

Cech NB: “Untargeted Metabolomics for Selection of Botanical Natural Products Prior to In Vitro or In Vivo Evaluation: the Role of Reference Materials” International Conference on the Science of Botanicals, Oxford, MS, April 9-12, 2018.

Kellogg JJ: “Workshop: Practical Implementation of Metabolomics for the Study of Botanicals” International Conference on the Science of Botanicals, Oxford, MS, April 9-12, 2018.

2017

Kellogg JJ, Tian DD, Oberlies NH, Paine MF, Cech NB: “Biochemometric Analysis Identifies Drug Metabolizing Enzyme Inhibitors from Green Tea (Camellia sinensis).” 2017 Southeast Regional Meeting of the American Chemical Society, Charlotte, NC November 7-11, 2017.

Paine MF: “A Systematic Approach to Select and Evaluate Natural Products as Precipitants of Pharmacokinetic Natural Product-Drug Interactions” 2nd Annual Joint CNPHARS-ASPET Meeting on Pharmacology, Hangzhou, China, November 3, 2017.

Cech NB: “New Approaches for Identifying the Biologically Active Components of Botanical Natural Products” 2nd Annual Joint CNPHARS-ASPET Meeting on Pharmacology, Hangzhou, China, November 3, 2017.

Kellogg JJ: “Comparative Analytical Approaches to Metabolomic Studies of Herbal Supplements and Natural Products” Central North Carolina Section of the American Chemical Society, Greensboro, NC, October 23, 2017.

Paine MF: “Intestinal UGTs as Targets for Pharmacokinetic Natural Product-Drug Interactions” 254th American Chemical Society National Meeting, Washington, DC, August 21, 2017.

Kellogg JJ, Kvalheim OM, Oberlies NHCech NB: “Multivariate Correlation for Botanical Supplements and Assigning Quantifiable Similarity” 254th American Chemical Society National Meeting, Washington, DC, August 22, 2017.

Kellogg JJ, Kvalheim OM, Oberlies NHCech NB: “Studies in Similarity: Metabolomics-Based Multivariate Correlation for Comparison of Natural Products” American Society of Pharmacognosy Annual Meeting, Portland, OR, July 31, 2017.

Paine MF: “Identification of Natural Products as Precipitants of Clinical Drug Interactions: Challenges and Opportunities” Gordon Research Conference on Drug Metabolism, Holderness, NH, July 11, 2017.

2016

Paine MF: “Natural Product-Drug Interaction Research: the Roadmap to Best Practices” Council for Responsible Nutrition Day of Science, Dana Point, CA, October 26, 2016.

Thummel KE: “New Frontiers for the Study and Prediction of Drug-Drug Interactions” 19th International Conference on Drug-Drug Interactions, Seattle, WA, June 20, 2016.

Cech NB: “Integrating Biological and Chemical Datasets To Identify Active Constituents Of Natural Product Mixtures” National Toxicology Program/ NIEHS Workshop, Bethesda, MD, April 26, 2016.

Symposia

Gordon Research Conference on Drug Metabolism, Holderness, NH, July 9, 2019: “Translational Approaches to Untangle Xenobiotic-Drug Interaction Mechanisms and Improve Pharmacotherapy”

Chair: Mary Paine

  • Dr. Elaine Tseng (Pfizer) “Optimizing in vitro tools for successful translation of time-dependent inhibitors”
  • Dr. John Harrelson (Pacific Univ) “Variety is the spice of life: pre-clinical approaches to evaluate mechanisms of cinnamaldehyde-drug interactions”
  • Dr. Jash Unadkat (UW and NaPDI Center co-investigator) “Cannabinoid-drug interactions: getting into the weeds”
  • Dr. Janne Backman (Univ of Helsinki) “Clinical approaches to untangle complex drug-drug interaction mechanisms”

EB/ASPET, Orlando, FL, April 6, 2019: “Natural Product-Drug Interactions: Complex Mechanisms and Public Health Impact”

Co-chairs: Mary Paine and Amy Roe

  • Dr. Amy Roe, co-chair (Procter & Gamble and EAP member): “Botanical-drug interaction assessment: a critical tier in a systematic approach to botanical safety”
  • Dr. Chuan Li (Shanghai Institute of Materia Medica): “Chinese herbal medicines as objects or precipitants of natural product-drug interactions”
  • Dr. Brandon Gufford (Covance, Inc. and NaPDI Center collaborator): “Sharing is caring: user-centered development of a natural product-drug interaction information portal”
  • Dr. Dan-Dan Tian (WSU and NaPDI Center trainee): “Differential effects of silymarin on pitavastatin disposition in rodent models of simple fatty liver versus nonalcoholic steatohepatitis: a natural product-disease-drug interaction”
  • Dr. Bill Gurley (University of Arkansas for Medical Sciences): “‘…Not intended to diagnose, treat, cure or prevent any disease’: 25 years of botanical dietary supplement usage and the lessons learned”

Other

Conference paper

Boyce RD, Ragueneau-Majlessi I, Yu J, Tay-Sontheimer J, Kinsella C, Chou E, Brochhausen M, Judkins J, Gufford BT, Pinkleton BE, Cooney R, Paine MF, McCune JS. Developing User Personas to Aid in the Design of a User-Centered Natural Product-Drug Interaction Information Resource for Researchers. AMIA Annual Symposium proceedings. AMIA Symposium. 2018:279-287.

Judkins J, Tay-Sontheimer J, Boyce RD, and Brochhausen M: “Extending the DIDEO Ontology to Include Entities from the Natural Product Drug Interaction Domain of Discourse” 6th International Workshop on Vaccine and Drug Ontology Studies, International Conference on Biomedical Ontology, Newcastle University, UK, September 13-15, 2017.

Webinar

Paine MF: “Natural Product-Drug Interactions: Case Studies from the NaPDI Center” SOLVO Biotechnology, October 25, 2017.

Themed issue

Clinical Pharmacy & Therapeutics Picture1

“Botanicals”

Co-editors: Mary Paine and Amy Roe

September 2018

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