The purpose of the NaPDI Center recommended approaches is to help researchers develop evidence-based, standardized methods to address the unique challenges of natural product-drug interaction research. Addressing these challenges requires a multidisciplinary team of clinical pharmacologists, natural products and analytical chemists, and biomedical informaticists. The recommended approaches are intended to be dynamic and reflective of the most up-to-date evidence currently available.
The rationale for creating the NaPDI Center, decision trees developed by the NaPDI Center to enhance the conduct of natural product-drug interaction studies, and a framework for communicating results to the multidisciplinary scientists interested in the NaPDI Center’s interaction projects are outlined in the following NaPDI publication: Paine MF, Shen DD, McCune JS. Recommended Approaches for Pharmacokinetic Natural Product-Drug Interaction Research: a NaPDI Center Commentary. Drug Metab Dispos 46:1041-5, 2018. PMID: 29735755.