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The National Institutes of Health, National Center for Complementary and Integrative Health (NCCIH) has created a Natural Product-Drug Interaction (NaPDI) Center of Excellence to address the lack of consistency in design, implementation, and documentation of studies to assess clinical relevance of natural product-drug interactions (grant U54 AT008909) and documentation of studies to assess clinical relevance of natural product-drug interactions.

The NaPDI Center consists of three Scientific Cores (Pharmacology, Analytical, and Informatics), along with an Administrative Core that coordinates activities between the Scientific Cores and liaises between the NaPDI Investigators and NCCIH program officials.

The NaPDI Center has two overarching goals:

Leadership Team

3Mary F. Paine, RPh, PhD
Principal Investigator, Administrative Core Leader, Pharmacology Core Leader
Professor
Department of Pharmaceutical Sciences
Washington State University

2Richard D. Boyce, PhD
Informatics Core Leader
Associate Professor
Department of Biomedical Informatics
School of Medicine, University of Pittsburgh

1Nicholas H. Oberlies, PhD
Analytical Core Leader
Professor
Medicinal Chemistry and Pharmacognosy
Department of Chemistry and Biochemistry
University of North Carolina, Greensboro

4D. Craig Hopp, PhD
Program Officer
Deputy Director
Division of Extramural Research
National Center for Complementary and Integrative Health

5Nadja B. Cech, PhD
Professor
Analytical Chemistry
Department of Chemistry and Biochemistry
The University of North Carolina at Greensboro


Administrative Core

Mary F. Paine, RPh, PhD
Principal Investigator, Administrative Core Leader, Pharmacology Core Leader
Associate Professor
Department of Pharmaceutical Sciences
Washington State University

Deena L. Hadi, BS
Program Manager
Department of Pharmaceutical Sciences
Washington State University

Kenneth E. Thummel, PhD
Professor and Milo Gibaldi Endowed Chair
Department of Pharmaceutics
School of Pharmacy
University of Washington

_____________________

Pharmacology Core

John D. Clarke, PhD
Assistant Professor
Department of Pharmaceutical Sciences
College of Pharmacy
Washington State University

Allan Rettie, PhD
Professor
Department of Medicinal Chemistry
School of Pharmacy
University of Washington

Jash Unadkat, PhD
Milo Gibaldi Endowed Professor
Department of Pharmaceutics
School of Pharmacy
University of Washington

Analytical Core

Nadja B. Cech, PhD
Professor
Analytical Chemistry
Department of Chemistry and Biochemistry
The University of North Carolina at Greensboro

Kenneth E. Thummel, PhD
Professor and Milo Gibaldi Endowed Chair
Department of Pharmaceutics
School of Pharmacy
University of Washington

_____________________

Informatics Core

Rebecca L. Cooney, MS
Clinical Associate Professor
The Edward R. Murrow College of Communication
Washington State University

Bruce Pinkleton, PhD
Professor and Dean
The Edward R. Murrow College of Communication
Washington State University

Sandra Kane-Gill, PharmD, MS, FCCM, FCCP
Professor
School of Pharmacy
University or Pittburgh

External Advisory Panel

Russ B. Altman, MD, PhD
Professor of Bioengineering, Genetics, Medicine and Biomedical Data Science (and Computer Science, by courtesy)
Department of Bioengineering
Stanford University

Shiew-Mei Huang, PhD
Deputy Director
Office of Clinical Pharmacology
Center for Drug Evaluation and Research
United States Food and Drug Administration

Ah-Ng Tony Kong, PhD
Distinguished Professor, Glaxo Endowed Chair in Pharmaceutics
Department of Pharmaceutics
Ernest Mario School of Pharmacy
Rutgers University

Amy L. Roe, PhD
Principal Toxicologist
Product Safety and Regulatory Affairs
The Procter and Gamble Company

R21 Grantees

John Clarke, PhD
Washington State University College of Pharmacy and Pharmaceutical Sciences
Enteric and Hepatic Transporter Mechanisms for Pharmacokinetic Natural Product-Drug Interactions

Bill Gurley, PhD
University of Mississippi College of Pharmacy
In Vitro Screening of a Unique Botanical Extract Collection for Herb-Drug Interaction (HDI) Potential

Collaborators

Ryan Vandrey, PhD
Co-Investigator
Associate Professor
School of Medicine, Department of Psychiatry and Behavioral Sciences
Johns Hopkins School of Medicine

Elise Weerts, PhD
Co-Investigator
Professor
School of Medicine, Department of Psychiatry and Behavioral Sciences
Johns Hopkins School of Medicine

Brandon T. Gufford, PharmD, PhD
NaPDI Collaborator
Adjunct Assistant Professor of Medicine
Department of Medicine, Division of Clinical Pharmacology
Indiana University School of Medicine

Bill J. Gurley, PhD
NaPDI Collaborator
Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Arkansas for Medical Sciences

Qualyst Transporter Solutions, LLC
NaPDI Industry Partner

Solvo Biotechnology
NaPDI Industry Partner

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