Good management and stewardship of data generated by the NaPDI Center are key tenets of the goal to provide rigorous, evidence-based information regarding natural-product drug interactions. This recommended approach addresses the four foundational FAIR data principles: findability, accessibility, interoperability, and reusability. Included in the recommendation are suggestions for data standardization, representation, metadata, quality assurance, and publishing. These suggestions reflect the NaPDI Center’s experience creating and maintaining a database and public portal designed to provide researchers with answers to key questions regarding natural product-drug interactions. The recommended approach is being written as Community Group Report and will be published by the World Wide Web Consortium (W3C) Semantic Web in Health Care and Life Sciences Community Group. The report is current a draft open for comments. Interested stakeholders can contact us at firstname.lastname@example.org or post a comment in the natural product – drug interactions topic at forums.dikb.org.