Kratom products contain a variety of alkaloid compounds responsible for reported pharmacologic action including opiate-like effects1-3. The primary active alkaloid is mitragynine, and other oxindole and indole alkaloids exist in M. speciosa such as 7-hydroxymitraginine1-3. Even though the compound has been used for generations in Thailand and Malaysia as component of traditional medicine1-3, rigorous content characterization of the plant and kratom products have been conducted much more recently. Further study is needed to establish kratom safety, efficacy, and potential for drug interactions5.
Center of Excellence for Natural Product-Drug Interaction Research