(Mitragyna speciosa)

Kratom (Mitragyna speciosa) is a member of the coffee family native to Southeast Asia. Dried kratom leaves are used to manufacture various products marketed as dietary supplements touted for their analgesic and stimulant effects. Naturally occurring alkaloids within kratom leaves in conjunction with biologically generated metabolites following human consumption likely drive physiologic effects and may mediate clinically meaningful interactions with co-administered drug products.