About the study:

The purpose of this research study is to determine whether goldenseal, a commercially available natural product, interferes with a protein in the gut that helps with metformin absorption, using midazolam as a probe to monitor for goldenseal effect. This study will consist of three study arms. During Arm 1, you will receive a single low dose of midazolam. During Arm 2, you will receive the same dose of midazolam plus a single dose of a well-characterized goldenseal product. During Arm 3, you will self-administer goldenseal three times daily for 27 days followed by the midazolam and goldenseal on the 28^th day. Blood will be drawn from an intravenous catheter following administration of midazolam. Urine samples will also be collected. You will receive a screening medical exam and will undergo routine blood and urine laboratory tests prior to participating in the study. Roughly 50 hours of active participation (over the span of 5 weeks) is necessary to complete the study.

Learn more about The Center of Excellence for Natural Product-Drug Interaction Research at napdi.org