The purpose of this research study is to determine how the body processes key constituents of kratom, an herbal product, and to evaluate whether kratom alters enzymes that break down the drugs midazolam and dextromethorphan in the body. This study will consist of Arm 2 where you will receive a single dose of midazolam plus dextromethorphan alone (part a) and with kratom (part b). Blood will be drawn from an intravenous line following administration of kratom or midazolam plus dextromethorphan. Urine samples will also be collected. You will receive a screening medical exam and will undergo routine blood and urine laboratory tests, as well as a urine toxicology screen, for common drugs of abuse prior to participating in the study.
We are seeking healthy female subjects between the ages of 18-55.